Anthropology and Human Genetics

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Cremer M, Schmid VJ, Kraus F, Markaki Y, Hellmann I, Maiser A, Leonhardt H, John S, Stamatoyannopoulos J and Cremer T (2017). Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters. Epigenetics Chromatin, 10, 39. PubMed

Schmid VJ, Cremer M, Cremer T (2017). Quantitative analyses of the 3D nuclear landscape recorded with super-resolved fluorescence microscopy. Methods 123: 33-46


Cremer T, Cremer M, Cremer C (2017) Der Zellkern - eine Stadt in der Zelle: Teil 1: Chromosomenterritorien und Chromatindomänen. Biologie in unserer Zeit 46(5): 290-99


Hübner B, Lomiento M, Mammoli F, Illner D, Markaki Y, Ferrari S, Cremer M, Cremer T (2015) Remodeling of nuclear landscapes during human myelopoietic cell differentiation maintains co-aligned active and inactiv nuclear compartments. Epigenetics & Chromatin 8:47

Cremer T, Cremer M, Hübner B, Strickfaden H, Smeets D, Popken J, Sterr M, Markaki J, Rippe K, Cremer C (2015) The 4D nucleome: Evidence for a dynamic nuclear landscape based on co-aligned active and inactive nuclear compartments. FEBS Letters 589: 2931-2943


Smeets D, Markaki Y, Schmid VJ, Kraus F, Tattermusch A, Cerase A, Sterr M, Fiedler S, Demmerle J, Popken J, Leonhardt H, Brockdorff N, Cremer T, Schermelleh L, Cremer M (2014) Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci. Epigenetics & Chromatin 7:8


Markaki Y, Smeets D, Cremer M, Schermelleh L (2013) Fluorescence in situ hybridization applications for super-resolution 3D structured illumination microscopy. Methods Mol Biol 950: 43-64

Walczak A, Szczepankiewicz A, Ruszczycki B, Zamłyńska K, Dzwonek J, Wilczek E, Żybura-Broda K, Rylski M, Szczepińska T, Pawłowski K, Włodarczyk J, Szczerbal5, Marek Świtoński I, Cremer M, Wilczyński G (2013) Novel higher-order epigenetic regulation of bdnf gene upon seizures. J Neuroscience 33: 2507-11


Cremer M, Markaki Y, Zunhammer A, Cremer C,  Cremer T (2012) Chromatin in the Cell Nucleus: Higher-order Organization. Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0005768.pub2

Markaki Y, Smeets D, Fiedler S,  Schmid VJ, Schermelleh L, Cremer T, Cremer M (2012) The potential of 3D-FISH and super-resolution structured illumination microscopy for studies of 3D nuclear architecture. BioEssays 34 (5): 412-26

Cremer T, Markaki Y, Hübner B, Zunhammer A, Strickfaden H, Beichmanis S, Heß M, Schermelleh L, Cremer M and Cremer C (2012) Chromosome territory organisation within the nucleus (2012) Advances in Molecular Biology and Medicine (Vol. 1). Epigenetic Regulation and Epigenomics Edited by Robert A. Meyers.Wiley-VCH. Vol 1: 451-483


Jost KL, Haase S, Smeets D, Schrode N, Schmiedel JM, Bertulat B, Herzel H, Cremer M, Cardoso MC (2011) 3D-image analysis platform monitoring relocation of pluripotency genes during reprogramming. Nucleic Acids Research 39 (17): e113

Cremer T und Cremer M (2011) Über ethische Verantwortbarkeit und Gewissensfreiräume (1) Freigabe der Präimplantationsdiagnostik: Ergebnisoffene, genetische Beratung und weltanschauliche Dimension der PID-Debatte. Gyne 32. Jahrg: 28-32 (in German)

T Cremer und M Cremer (2011) Freigabe der Präimplantationsdiagnostik: Über ethische Verantwortbarkeit und Gewissensfreiräume Gyne 32. Jahrg: 20 – 23 (in German)

Teller K, Illner D, Thamm S, Casas-Delucchi CS, Versteeg R, Indemans M, Cremer T, Cremer M (2011) A top-down analysis of Xa- and Xi-territories reveals differences of higher order structure at  ≥20 Mb genomic  length scales. Nucleus  2 (5): 465-477



Cremer T and Cremer M (2010) Chromosome territories. Cold Spring Harb Perspect Biol2: a003889

Illner D, Zinner R, Handtke V, Rouquette J, Strickfaden H, Lanctot C, Conrad M, Seiler A, Imhof A, Cremer T, Cremer M (2010) Remodeling of nuclear rchitecture by the thiodioxopiperazine metabolite chaetocin. Exp Cell Res 316: 1662-80

Solovei I and Cremer M (2010) 3D-FISH on Cultured Cells Combined with Immunostaining. Methods Mol Biol 659: 117-26


Hübner B, Strickfaden H, Müller S, Cremer M, Cremer T. Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure. Eur Biophys J. 2009 Jul;38(6):729-47.

Müller S, Cremer M, Neusser, Grasser F, Cremer T (2009) Quantum dots in multi-colour fluorescence in situ hybridisation: a technical note. Cytogenetics and Genome Research, 124: 351-9


Cremer M, Müller S, Solovei I, Cremer T (2008) 3D FISH und Zellkernarchitektur. Medizinische Genetik DOI 10.1007/s11825-008-0132-9

Müller S, Cremer M, Neusser, Grasser F, Cremer T (2008) Quantum dots in multi-colour fluorescence in situ hybridisation: a technical note. Cytogenetics and Genome Research, in press

Postberg J, Heyse K, Cremer M, Cremer T, Lipps HJ1 (2008) Spatial and temporal plasticity of chromatin during programmed DNA-reorganization in Stylonychia macronuclear development; Epigenetics and Chromatin 1:3

Cremer M, Grasser F, Lanctot C, Müller S, Neußer M, Solovei I, Zinner R, Cremer T (2008) Multicolor 3D-FISH for imaging interphase chromosomes. Methods Mol Biol 463: 205-39

Grasser F, Neusser M, Fiegler H, Thormeyer T, Cremer M, Carter N, Cremer T, Stefan Müller S (2008) Replication timing correlated spatial chromatin arrangements in cancer and primate interphase nuclei; J Cell Sci 121: 1876-188


Cremer M, Grasser F, Lanctot C, Müller S, Neußer M, Solovei I, Zinner R, Cremer T(2007) Multicolor 3D-FISH for imaging interphase chromosomes. Methods in Molecular Biology “The Nucleus” edited by R. Hancock

Zinner R, Teller K, Versteeg R, Cremer T, Cremer M (2007) Biochemistry meets nuclear architecture: Multicolor immuno-FISH for co-localization analysis of chromosome segments and differentially expressed gene loci with various histone methylations. Advan Enzyme Regul 47:223-41

Tashiro S, Cremer M, Solovei I, Cremer T (2007) Nuclear architecture: Topology and function of chromatin- and non-chromatin nuclear domains. In: Nuclear Dynamics, Molecular Biology and Visualization of the nucleus. Springer, eds. K. Nagata and K. Takeyasu

Müller S, Neusser M, Köhler D, Cremer M (2007) Preparation of complex DNA probe sets for 3D FISH with up to six different fluorochromes CSH Protocols; doi:10.1101/pdb.prot4730

Cremer M, Müller S, Köhler D, Brero A, Solovei I (2007) Cell preparation and multicolor FISH in 3D preserved cultured mammalian cells. CSH protocols. doi:10.1101/pdb.prot4723

Lanctôt C, Cheutin T, Cremer M, Cavalli G, Cremer T (2007) Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions (2007). Nature Rev Genet 8: 105-115 

Cremer M, Müller S, Köhler D, Brero A, Solovei I (2007) Cell preparation and multicolor FISH in 3D preserved cultured mammalian cells. CSH protocols. doi:10.1101/pdb.prot4723

Müller S, Neusser M, Köhler D, Cremer M. (2007) Preparation of complex DNA probe sets for 3D FISH with up to six different fluorochromes CSH Protocols; doi:10.1101/pdb.prot4730

Küpper K, Kölbl A, Biener D, Dittrich S, v. Hase J, Thormeyer T, Fiegler H, Carter N, Speicher MR, Cremer T, Cremer M (2007) Radial chromatin positioning is shaped by local gene density not by gene expression. Chromosoma 116: 285-306


Walter J, Joffe B, Bolzer A, Albiez H, Benedetti PA, Müller S, Speicher MR, Cremer T, Cremer M, Solovei I (2006) Towards many colors in FISH on 3D-preserved interphase nuclei. Cytogenet Genome Res 114: 367-378

Cremer T, Cremer M, Dietzel S, Müller S, IrinaSolovei I Fakan S (2006) Chromosome territories – a functional nuclear landscape. Current Opinion in Cell Biology 18: 307-316

Cremer M, Weiereich C, Solovei I (2006) Multicolor 3D-FISH in vertebrate cells. edited by The Epigenome Network of Excellence

Albiez H, Cremer M, Tiberi L, Vecchio L, Schermelleh L, Dittrich S, Joffe B, Küpper K, Leonhardt H, Solovei I, Thormeyer T, Yang S, Rohr K, von Hase J, Cremer C, Fakan S, Cremer T (2006) Chromosome territories and the interchromatin compartment form two separate networks in human cell nuclei. Chromosome Res 14: 707-733

Zinner R, H Albiez, J Walter, AHF Peters, T Cremer, M Cremer (2006) Histone lysine methylation patterns in human cell types are arranged in distinct three-dimensional nuclear zones. Histochemistry and Cell Biology 125: 3-19


Cremer M, R Zinner, S Stein, H Albiez, B Wagler, C Cremer, and T Cremer. (2004) Nuclear architecture of heterochromatin in normal and tumor cell nuclei visualized by immunostaining of methylated histone H3. Europ J Histochem 48: 15-28

Kreth G, Finsterle J, v. Hase J, Cremer M, Cremer C (2004) Radial arrangement of chromosome territories in human cell nuclei: a computer model approach based on gene density indicates a probabilistic global positioning code. Biophys J 86: 2803-2812


Cremer M, Küpper K, Wagler B, Wizelman L, v. Hase J, Weiland Y, Kreja L, Diebold J, Speicher MR, Cremer T (2003) Inheritance of gene-density related higher order chromatin arrangements in normal and tumor cell nuclei. J Cell Biol 162: 809-820

Walter J, Schermelleh L, Cremer M, Tashiro S, Cremer T (2003) Chromosome order in HeLa cells changes during mitosis and early G1, but is stably maintained during subsequent interphase stagesChromosome dynamics studied in human cells during cell cycle and recombinational repair. J Cell Biol 160: 685-97


Tanabe H, Habermann F, Solovei I, Cremer M, Cremer T (2002) Non-random radial arrangements of interphase chromosome territories: Evolutionary considerations and functional implications. Mutation Research 504: 37-45

Tanabe H, Müller S, Neusser M, von Hase J, Calcagno E, Cremer M, Solovei, I, Cremer C, Cremer T (2002) Thirty million years of evolutionary conservation in chromosome territory arrangements of primate cell nuclei. PNAS, USA, 99: 4424-4429

Solovei I, Walter J, Cremer M, Habermann F, Schermelleh L, Cremer T. (2002) FISH on three-dimensionally preserved nuclei. in: FISH: a practical approach. Oxford University press. Edited by J. Squire


Cremer M, von Hase J, Volm T, Brero A, Kreth G, Walter J, Fischer C, Solovei I, Cremer C, Cremer T (2001) General and cell type specific higher order chromatin arrangements in nuclei of diploid human cells. Chromosome Research  9: 541-567

Habermann F, Cremer M, Walter J, v. Hase J, Wienberg J, Cremer C, Cremer T, Solovei I. (2001)  Arrangements of macro- and microchromosomes in chicken cells, Chromosome Research 9:569-584


Cremer T, Kreth G, Koester H, Fink RHA, Heintzmann R, Cremer M, Solovei I, Zink D, Cremer C. (2000) Chromosome territories, interchromatin domain compartment and nuclear matrix: an integrated view of the functional nuclear architecture. Critical reviews in Eukaryotic Gene Expression 10: 179-212

Franz WM, Müller M, Herrmann R, Rothmann T, Frey N, Cremer M, Cohn RD, Campbell KP; Voit T, Katus HA (2000) Nonsense mutation of dystrophin exon 29 leads to an in-frame deletion in the rod domain disrupting its interaction with the myocardial but not the skeletal muscle sarcoglycan complex. Lancet 355: 1781-1785


Schermelleh L, Thalhammer S, Cremer T, Pösl H, Heckl W, Schütze K, Cremer M (1999) Laser microbeam microdissection and laser pressure catapulting as an approach for the generation of chromosome specific paint probes, BioTechniques 27:362-367


Spranger M, Spranger S, Tischendorf M, Meinck HM, Cremer M (1997) Myotonic dystrophy. The role of large repeat length in the development of mental retardation. Arch. Neurol. 54: 251-254

Kraus J, Weber R, Cremer M, Seebacher T, Fischer C, Schurra C, Jauch A, Lichter P,  Bensimon A, Cremer T, (1997) High resolution comparative hybridization to combed DNA fibers. Hum. Genet. 99: 374-380